The Dark Side of Human Optimisation: Nicotine, Peptides, NAD+ & the Enhanced Games | Longevity Doctor Explains

This week I'm joined by Dr Jack Kreindler, physician, healthtech entrepreneur and founder of WellFounded Health and the Centre for Health and Human Performance, and someone who has spent 26 years asking one of the most important questions in medicine, what does it mean to not just fix disease, but to truly enhance human life?We explore longevity, prevention, performance and what the most advanced medicine in the world is learning about how to live well for longer.Dr Jack Kreindler qualified in medicine and physiology from University College London and spent a decade as an emergency physician before founding the Centre for Health and Human Performance in Harley Street in 2007. He is an honorary clinical research fellow at Imperial College London, founder and CEO of WellFounded Health and a leading voice on healthy longevity, human performance and the future of medicine. He has worked with elite athletes, extreme environment explorers and high performance executives across the world.What we explore together:Why medicine is shifting from fixing disease to enhancing physiology and what that means for youWhat burning the candle at three ends is actually doing to your brain and bodyWhy cadence is king and how everything in nature and biology moves in wavesWhat the most advanced health testing actually looks like and what it tells usThe truth about longevity supplements, peptides and biohacking and who they actually work forWhy your history is still the most powerful diagnostic tool ever inventedWhat it really means to enhance a human life rather than just extend itLove, Sarah Ann 💛My book 'Healthy Shouldn't Be This Hard': https://www.amazon.co.uk/Healthy-Shouldnt-Be-This-Hard-ebook/dp/B0G1DHNRV5This episode is sponsored by:NOWATCH: The compassionate health tracker Connecting body and mind with unique stress recovery insights so you can live fully today👉 15% off with code LWBW15 at https://nowatch.com/PULSETTO: Vagus nerve stimulation for stress, sleep and calm👉 Use code SARAHANN at https://pulsetto.sjv.io/SARAHANNThe Great British Veg OutHow to support your gut, energy, and hormones by eating more, not less.👉 https://sarahmacklin.substack.com/p/t…Reset Your HealthIf your body feels off after stress, travel, or burnout, this is where to start.👉 https://sarahmacklin.substack.com/s/r...👉 Practical beats perfect. Here's a free 5-recipe PDF I use to support energy and stress during busy weeks.https://sarahannmacklin.com/5_free_recipes👉 If this resonates, you can join the thousands who read The Compassionate Cure each week.https://sarahmacklin.substack.com/Let's be friends!📷 Instagram: https://www.instagram.com/sarahannmacklin/📹 Subscribe: https://youtube.com/@livewellbewellsarah🐦 Twitter: https://x.com/SarahAnnMacklin📱 TikTok: https://www.tiktok.com/@livewellbewellpodcast💌 Newsletter: https://sarahmacklin.substack.com/Chapters00:00 Introduction02:59 How Jack's view of medicine changed over 26 years05:58 Burning the candle at three ends and what it costs you09:04 Why cadence is king in biology and life12:00 What a prevention first approach to health looks like18:00 Your history from one cell to 38 trillion21:02 What advanced health testing actually reveals30:00 Hormones, menopause and andropause33:02 Cardiovascular risk and how to assess it properly36:00 Brain health, dementia risk and what you can do now39:07 The gut microbiome and its role in everything42:00 Extreme environments and what they teach us about health45:08 Elite sport science applied to everyday health48:00 The longevity space and what the evidence actually shows51:07 Peptides, supplements and biohacking54:06 What works, what doesn't and how to know the difference57:07 AI and the future of personalised medicine66:04 The bell shaped curve and why nothing works for everyone69:08 What enhancing a human life really means72:00 Not dying dull and what Jack has learned75:02 Final thoughts on living well and being well