🧬 One Mutation, Massive Risk: EGFR T790M and Inherited Lung Cancer

🧬 Rare Variant, Real Risk: EGFR T790M and Lung Cancer Can lung cancer risk be inherited—even in never-smokers? 🫁🚭 In >3.3 million individuals, germline EGFR T790M was rare (~1 in 15,850) but strongly associated with lung cancer (OR 25.18). The association was particularly striking among never-smokers, and the variant showed remarkable lung-cancer specificity. A Southern Appalachian founder effect also revealed how genes, geography & history can converge on modern disease risk. 🗺️🧬 💡 A compelling case for refining genetic risk assessment and future targeted screening strategies.