Ep. 76 GU Oncology: ASCO Highlights & Impacts on Practice with Dr. Alan Tan

Is GU oncology entering a new era of early intensification and precision therapy? On this episode of the BackTable Tumor Board Podcast, Dr. Katy Beckermann and Dr. Alan Tan break down the latest GU oncology highlights from ASCO, including key updates in prostate, renal cell, and urothelial carcinoma. They discuss new data supporting HRR/BRCA-focused therapy in HSPC, the importance of early biomarker testing, and ongoing debates about overtreatment and real-world practice impact. --- Get the BackTable app https://www.backtable.com/app --- Timestamps 00:00 - Introduction 01:56 - Frontline Prostate Cancer & TALAPRO-3 Highlights 07:11 - PROTEUS Plenary Breakdown & Controversies 13:47 - RCC Rampart and ctDNA 19:47 - Bladder EV Pembro Updates 23:34 - Next-Gen Nectin-4 ADC 26:51 - Wrap-Up --- More about this episode The conversation covers the PROTEUS trial and perioperative intensification, RAMPART and Keynote-564 ctDNA findings in RCC, and new standards in perioperative bladder cancer treatment with EV plus pembrolizumab. Drs. Tan and Beckermann also discuss next-generation ADCs, pharmacogenomic toxicity considerations, and the promise of AI and ctDNA for patient selection and de-escalation strategies in advanced GU cancers. --- Resources TALAPRO-3 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2604126 PROTEUS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2603878 RAMPART Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1107494 KEYNOTE-564 ctDNA Biomarker Sub-Study https://www.urotoday.com/conference-highlights/asco-2026/asco-2026-kidney-cancer/169387-asco-2026-ctdna-analysis-in-participants-with-rcc-treated-with-adjuvant-pembrolizumab-in-the-keynote-564-trial.html --- BackTable Tumor Board is the go-to multidisciplinary podcast for medical oncologists, surgical oncologists, and other healthcare professionals that play an active role in cancer care. Download the free BackTable app to get early access to new episodes, cases, and courses curated by physicians in your specialty. ► https://www.backtable.com/app