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Podcast Episode

Longevity Beyond Biohacking: Dr. Jeff Gladden on Exponential Aging, Purpose, and Health Optimization - Part 1

Master Stress with Dr. S··11 September 2026·30 min

About this episode

Dr. S introduces a podcast series on longevity and interviews Dr. Jeffrey Gladden, a cardiologist-turned-longevity physician and founder of Gladden Longevity in Dallas. Gladden describes how, despite being told his labs were “normal for his age,” he experienced weight gain, fatigue, anxiety, brain fog, and depression in his 50s and felt conventional medicine offered only sick care. After a two-and-a-half-year functional and integrative medicine deep dive, he identified subclinical hypothyroidism, genetic thyroid conversion issues, hormonal depletion, and neurotransmitter challenges, and found targeted therapies plus meditation helped him recover. He explains aging is biologically exponential and outlines his five-circle systems approach—life energy (psychospiritual), longevity (hallmarks of aging), health, performance, and environments—guided by questions like “How good can I be?” and “How do we live young for a lifetime?” 00:00 Longevity Everywhere 01:58 Meet Dr Jeff Gladden 04:07 Cardiology Wake Up Call 06:37 When Aging Accelerates 08:05 Functional Medicine Breakthrough 12:00 Leaving Conventional Medicine 12:51 Courage Purpose Identity 17:16 Spiritual Roots And Psychedelics 20:27 Love Creates Joy 22:48 Five Circles Longevity System 27:28 How Good Can I Be 28:23 Part Two TeaserConnect with Dr Safia DebarDr Safia Debar Speaker / Coach | Medical Doctor | Breathwork Facilitator  One of Tatler's "Top 21 private doctors in Britain" 2020 www.drsafiadebar.com contact@drsafiadebar.com IG: @drsafiadebar Tiktok: drsafiadebar Find our free resources here: www.drsafiadebar.com/resource