100 years of insulin in 15 minutes

A hundred years ago, insulin was scraped from pig pancreases. Today, it’s made by bacteria in giant tanks. In the second part of a mini series on proteins, drug development and AI, Saloni tells the story of how insulin went from a crude animal extract to the first genetically-engineered drug, kickstarting the biotech industry along the way. Hard Drugs is a new podcast from Works in Progress and Open Philanthropy about medical innovation presented by Saloni Dattani and Jacob Trefethen. Saloni’s substack newsletter: https://www.scientificdiscovery.dev/ Jacob’s blog: https://blog.jacobtrefethen.com/  Books: Genentech: The beginnings of biotech by Sally Smith Hughes Articles: FDA (2007). Celebrating a Milestone: FDA's Approval of First Genetically-Engineered Product https://fda.report/media/110447/Celebrating-a-Milestone--FDA%27s-Approval-of-the-First-Genetircally-Engineered-Product.pdf  Genentech (2016). Cloning Insulin https://www.gene.com/stories/cloning-insulin  Arthur Riggs (2020). Making, Cloning, and the Expression of Human Insulin Genes in Bacteria: The Path to Humulin https://academic.oup.com/edrv/article/42/3/374/6042201  Podcasts: Novo Nordisk (Ozempic) by the Acquired podcast https://www.acquired.fm/episodes/novo-nordisk-ozempic  Acknowledgements: Aria Babu, editor at Works in Progress Adrian Bradley, on-site producer Anna Magpie, fact-checking Abhishaike Mahajan, cover art Atalanta Arden-Miller, art direction David Hackett, composer Works in Progress & Open Philanthropy