Two phase 3 clinical trials evaluated the efficacy and safety of oveporexton, an oral orexin receptor 2-selective agonist, for treating narcolepsy type 1 over a 12-week period. Participants receiving…
This academic review proposes a unified spectrum model for multiple sclerosis (MS) that challenges traditional, rigid phenotype classifications like RRMS, SPMS, and PPMS. The authors argue that…
This epiode is an extended version of the recently published episode on the examination and localization of eye movement disorders. The orginal paper details a comprehensive clinical framework for the…
This episode is a comprehensive review of a peper exploring the 2024 McDonald criteria, which represent a significant update to the global standards for diagnosing multiple sclerosis (MS). These…
This umbrella review evaluates the clinical efficacy and safety of two recently approved anti-amyloid antibodies, lecanemab and donanemab, for treating early-stage Alzheimer’s disease. By synthesizing…
This paper provides a comprehensive clinical framework for the examination and localization of eye movement disorders, emphasizing that the systematic bedside assessment serves as the primary tool for…
This comprehensive review examines the evolution and clinical potential of liquid biopsy, a non-invasive diagnostic method that analyzes biomarkers within bodily fluids. The text classifies primary…
This systematic review and meta-analysis evaluates the effectiveness and safety of therapeutic plasma exchange (TPE) for treating autoimmune neurological diseases (ANDs). By analyzing 38 studies…
Parsonage-Turner syndrome, also known as neuralgic amyotrophy, is a frequently misdiagnosed peripheral nerve disorder characterized by sudden, intense shoulder pain followed by muscle weakness and…
This clinical review examines the neurological complications associated with Merkel cell carcinoma (MCC), distinguishing between immune-mediated paraneoplastic syndromes and direct metastatic…
